Consider the Veeam Network transport mode if you use NFS datastores
I’m using Veeam Backup & Replication (currently 8.0 Update 3) in my lab environment to backup some of my VMs to a HP StoreOnce VSA. The VMs reside in a NFS datastore on a Synology DS414slim NAS, the StoreOnce VSA is located in a local datastore (RAID 5 with SAS disks) on one of my ESXi hosts. The Veeam backup server is a VM and it’s also the Veeam Backup Proxy.