Changes to supported .NET Frameworks for Exchange 2013/2016
Edit: If you have already installed .NET 4.6.1, check this blog post on how to remove it (You Had Me At EHLO…)
Microsoft Exchange heavily relies on Microsoft .NET Framework. Because of this, Microsoft provides a matrix for the supported Microsoft .NET Frameworks. Mostly unknown is the fact, that Exchange doesn’t support the every Microsoft .NET Framework, and this is causing trouble sometimes. Some admins simply install the latest .NET releases because “it doesn’t hurt”. Well… it hurts!

